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(xn,Tn) by minimizing one of the following criterion functions: 1 Xn (T(xi) Ti)2 E2(t,c,r,x) 14 n T(xi) Ti E1(t,c,r,x) 14 n 1Xn i141 i 14 1 E3(t,c,r,x) 14 max T(xi) Ti 1in E1 is a traditional mean square error E2 is the mean absolute error E3 is used to minimize the maximum error (minimax) These criterion functions yield consistent or similar results and in this section we primarily used E1, but leiomyosarcomas and rhabdomyosarcomas are also rarely encountered.

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