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© 1999 by CRC Press LLC (6. Rev. 25 A sentry is always on duty. The butyltins generally show a level of toxicity that prevents them being used in application in contact with foodstuffs. In some cases, the branched-chain a-hydroxyacids, most prominently a-hydroxyisovaleric acid, are also excreted, and a sotolone derivative of a-ketobutyric acid, whose decarboxylation is impaired by accumulation of a-keto-b-methylvaleric acid, is responsible for the characteristic odor of the urine and sweat.

In recessive in- heritance the clinical signs of the disease are evident only when both copies of the gene have the mutation.

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